Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

ABSTRACT: Aurora kinases are mitotic enzymes involved in centrosome maturation and separation, spindle assembly and stability, and chromosome condensation, segregation, and cytokinesis and represent well known targets for cancer therapy because their deregulation has been linked to tumorigenesis. The availability of suitable markers is of crucial importance to investigate the functions of Auroras and monitor kinase inhibition in in vivo models and in clinical trials. Extending the knowledge on Aurora substrates could help to better understand their biology and could be a source for clinical biomarkers. Using biochemical, mass spectrometric, and cellular approaches, we identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site. MYBBP1A is phosphorylated in noco

SUBMITTER: Perrera C 

PROVIDER: S-EPMC2852913 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature