Selenium compounds activate early barriers of tumorigenesis.
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ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC2852943 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Selenium compounds activate early barriers of tumorigenesis.
Wu Min M Kang Mandy M MM Schoene Norberta W NW Cheng Wen-Hsing WH
The Journal of biological chemistry 20100215 16
Selenium chemoprevention by apoptosis has been well studied, but it is not clear whether selenium can activate early barriers of tumorigenesis, namely senescence and DNA damage response. To test this hypothesis, we treated normal and cancerous cells with a gradient concentration of sodium selenite, methylseleninic acid and methylselenocysteine for 48 h, followed by a recovery of 1-7 days. Here we show that selenium compounds at doses of </=LD(50) can induce cellular senescence, as evidenced by t ...[more]
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