Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study.

ABSTRACT:

Background/objectives

Age-related changes in blood coagulation and fibrinolysis are associated with increased risk of thrombotic events. Inherited deficiencies of coagulation proteins, such as factor V (FV) Leiden and prothrombin G20210A, explain a small fraction of venous thromboembolic disease (VTE). Additional genetic factors are likely to underlie the etiology of VTE, some of which may become manifest at older ages.

Methods

We tested 290 common SNPs within 51 thrombosis and inflammation genes for association with VTE in the Cardiovascular Health Study, a large, prospective cohort of older adults followed for up to 12 years.

Results

There were 184 VTE events that occurred at mean age of 78 years. TagSNPs within four genes encoding FXIII subunit A (F13A), FVII activ

SUBMITTER: Reiner AP 

PROVIDER: S-EPMC2853009 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature