Genome comparison and context analysis reveals putative mobile forms of restriction-modification systems and related rearrangements.

ABSTRACT: The mobility of restriction-modification (RM) gene complexes and their association with genome rearrangements is a subject of active investigation. Here we conducted systematic genome comparisons and genome context analysis on fully sequenced prokaryotic genomes to detect RM-linked genome rearrangements. RM genes were frequently found to be linked to mobility-related genes such as integrase and transposase homologs. They were flanked by direct and inverted repeats at a significantly high frequency. Insertion by long target duplication was observed for I, II, III and IV restriction types. We found several RM genes flanked by long inverted repeats, some of which had apparently inserted into a genome with a short target duplication. In some cases, only a portion of an apparently complete RM s

SUBMITTER: Furuta Y 

PROVIDER: S-EPMC2853133 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature