Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction.

ABSTRACT:

Background

Although the mechanistic details of the vesicle transport process from the cell body to the nerve terminal are well described, the mechanisms underlying vesicle traffic within nerve terminal boutons is relatively unknown. The actin cytoskeleton has been implicated but exactly how actin or actin-binding proteins participate in vesicle movement is not clear.

Results

In the present study we have identified Nonmuscle Myosin II as a candidate molecule important for synaptic vesicle traffic within Drosophila larval neuromuscular boutons. Nonmuscle Myosin II was found to be localized at the Drosophila larval neuromuscular junction; genetics and pharmacology combined with the time-lapse imaging technique FRAP were used to reveal a contribution of Nonmuscle Myosin II to sy

SUBMITTER: Seabrooke S 

PROVIDER: S-EPMC2853426 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature