Systematic discovery of regulatory motifs in Fusarium graminearum by comparing four Fusarium genomes.

ABSTRACT:

Background

Fusarium graminearum (Fg), a major fungal pathogen of cultivated cereals, is responsible for billions of dollars in agriculture losses. There is a growing interest in understanding the transcriptional regulation of this organism, especially the regulation of genes underlying its pathogenicity. The generation of whole genome sequence assemblies for Fg and three closely related Fusarium species provides a unique opportunity for such a study.

Results

Applying comparative genomics approaches, we developed a computational pipeline to systematically discover evolutionarily conserved regulatory motifs in the promoter, downstream and the intronic regions of Fg genes, based on the multiple alignments of sequenced Fusarium genomes. Using this method, we discovered 73 candid

SUBMITTER: Kumar L 

PROVIDER: S-EPMC2853525 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature