Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.

ABSTRACT:

Background

Cell-based therapy holds great promises for demyelinating diseases. Human-derived fetal and adult oligodendrocyte progenitors (OPC) gave encouraging results in experimental models of dysmyelination but their limited proliferation in vitro and their potential immunogenicity might restrict their use in clinical applications. Virtually unlimited numbers of oligodendroglial cells could be generated from long-term self-renewing human (h)-derived neural stem cells (hNSC). However, robust oligodendrocyte production from hNSC has not been reported so far, indicating the need for improved understanding of the molecular and environmental signals controlling hNSC progression through the oligodendroglial lineage. The aim of this work was to obtain enriched and renewable cultures of

SUBMITTER: Neri M 

PROVIDER: S-EPMC2853578 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature