Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states.

ABSTRACT:

Background

Because of its wide spectrum of clinical manifestations and its well-defined immunological complications, leprosy is a useful disease for studying genetic regulation of the host response to infection. We hypothesized that polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene, for a cytosolic receptor known to detect mycobacteria, are associated with susceptibility to leprosy and its clinical outcomes.

Methods

We used a case-control study design with 933 patients in Nepal. Our study included 240 patients with type 1 (reversal) reactions and 124 patients with type 2 (erythema nodosum leprosum) reactions. We compared the frequencies of 32 common polymorphisms in the NOD2 gene region between patients with the different clinical types

SUBMITTER: Berrington WR 

PROVIDER: S-EPMC2853728 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature