Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men.

ABSTRACT:

Context

Although age-related declines in dehydroepiandrosterone sulfate (DHEAS) and testosterone are associated with cardiovascular risk, it remains to be determined whether replacement of these hormones improves cardiovascular risk factors.

Objective

This study sought to determine the effect of long-term replacement of dehydroepiandrosterone (DHEA) in elderly men and women and testosterone in elderly men on lipid and lipoprotein concentrations and particle sizes.

Methods

A 2-yr randomized, placebo-controlled, double-blind study was conducted in 87 elderly men with low levels of DHEAS and bioavailable testosterone and 57 elderly women with low levels of DHEAS. Among elderly men, 29 received DHEA (75 mg/d), 27 received testosterone (5 mg/d), and 31 received placebo. Am

SUBMITTER: Srinivasan M 

PROVIDER: S-EPMC2853990 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature