CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

ABSTRACT:

Background

Depression and alcohol abuse or dependence (AUD) co-occur in the general population more frequently than expected by chance. Alcohol use influences the circadian rhythms generated by the central pacemaker in the suprachiasmatic nucleus, and circadian rhythm alterations in turn are common in depressive disorders as well as among persons addicted to alcohol.

Methods

32 SNPs in 19 circadian clockwork related genes were analyzed using DNA from 76 individuals with comorbid depression and AUD, 446 individuals with AUD and 517 healthy controls with no psychiatric diagnosis. The individuals participated in a nationwide health examination study, representative of the general population aged 30 and over in Finland.

Results

The CLOCK haplotype TTGC formed by SNPs rs38

SUBMITTER: Sjoholm LK 

PROVIDER: S-EPMC2854106 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature