Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is characterized by a neurodegenerative progression that alters cognition. On a phenotypical level, cognition is evaluated by means of the MiniMental State Examination (MMSE) and the post-mortem examination of Neurofibrillary Tangle count (NFT) helps to confirm an AD diagnostic. The MMSE evaluates different aspects of cognition including orientation, short-term memory (retention and recall), attention and language. As there is a normal cognitive decline with aging, and death is the final state on which NFT can be counted, the identification of brain gene expression biomarkers from these phenotypical measures has been elusive.

Methodology/principal findings

We have reanalysed a microarray dataset contributed in 2004 by Blalock et al. of 31

SUBMITTER: Gomez Ravetti M 

PROVIDER: S-EPMC2854141 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature