The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.

ABSTRACT: The "Community Effect" denotes intra-territorial signaling amongst cells which constitute a particular tissue or embryonic progenitor field. The cells of the territory express the same transcriptional regulatory state, and the intra-territorial signaling is essential to maintenance of this specific regulatory state. The structure of the underlying gene regulatory network (GRN) subcircuitry explains the genomically wired mechanism by which community effect signaling is linked to the continuing transcriptional generation of the territorial regulatory state. A clear example is afforded by the oral ectoderm GRN of the sea urchin embryo where cis-regulatory evidence, experimental embryology, and network analysis combine to provide a complete picture. We review this example and consider less wel

SUBMITTER: Bolouri H 

PROVIDER: S-EPMC2854306 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature