Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis.

ABSTRACT:

Rationale

The mechanisms contributing to alveolar formation are poorly understood. A better understanding of these processes will improve efforts to ameliorate lung disease of the newborn and promote alveolar repair in the adult. Previous studies have identified impaired alveogenesis in mice bearing compound mutations of fibroblast growth factor (FGF) receptors (FGFRs) 3 and 4, indicating that these receptors cooperatively promote postnatal alveolar formation.

Objectives

To determine the molecular and cellular mechanisms of FGF-mediated alveolar formation.

Methods

Compound FGFR3/FGFR4-deficient mice were assessed for temporal changes in lung growth, airspace morphometry, and genome-wide expression. Observed gene expression changes were validated using quantitative rea

SUBMITTER: Srisuma S 

PROVIDER: S-EPMC2854333 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature