Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals.

ABSTRACT:

Background/aims

Fasting plasma glucose (FPG) levels correlate with cardiovascular disease and mortality in both diabetic and non-diabetic subjects. G6PC2 encodes a pancreatic islet-specific glucose-6-phosphatase-related protein and G6pc2-null mice were reported to exhibit decreased blood glucose levels. Two recent genome-wide association studies have implicated a role for G6PC2 in regulation of FPGlevels in the general European population and reported the strongest association with the rs560887 SNP. The purpose of this study was to replicate this association in our independent epidemiological samples.

Methods

DNA samples from non-Hispanic white Americans (NHWs; n = 623), Hispanic Americans (n = 410) and black Africans (n = 787) were genotyped for rs560887 using TaqMan alleli

SUBMITTER: Demirci FY 

PROVIDER: S-EPMC2855271 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature