Model-based prediction of defective DNA mismatch repair using clinicopathological variables in sporadic colon cancer patients.

ABSTRACT:

Background

: Colon cancers with defective DNA mismatch repair (MMR) have a favorable prognosis and may lack benefit from 5-fluorouracil-based adjuvant chemotherapy. The authors developed models to predict MMR deficiency in sporadic colon cancer patients using routine clinical and pathological data.

Methods

: TNM stage II and III colon carcinomas (n = 982) from 6 5-fluorouracil-based adjuvant therapy trials were analyzed for microsatellite instability and/or MMR protein expression. Tumor-infiltrating lymphocytes (TILs) were quantified (n = 326). Logistic regression and a recursive partitioning and amalgamation analysis were used to identify predictive factors for MMR status.

Results

: Defective MMR was detected in 147 (15%) cancers. Tumor site and histologic grade were

SUBMITTER: Sinicrope F 

PROVIDER: S-EPMC2855300 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature