Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar).

ABSTRACT:

Background

Type I and type II interferons (IFNs) exert their effects mainly through the JAK/STAT pathway, which is presently best described in mammals. STAT1 is involved in signaling pathways induced by both types of IFNs. It has a domain-like structure including an amino-terminus that stabilizes interaction between STAT dimers in a promoter-binding situation, a coiled coil domain facilitating interactions to other proteins, a central DNA-binding domain, a SH2 domain responsible for dimerization of phosphorylated STATs and conserved phosphorylation sites within the carboxy terminus. The latter is also the transcriptional activation domain.

Results

A salmon (Salmo salar) STAT1 homologue, named ssSTAT1a, has been identified and was shown to be ubiquitously expressed in various

SUBMITTER: Skjesol A 

PROVIDER: S-EPMC2855521 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature