Microrna profiling analysis of differences between the melanoma of young adults and older adults.

ABSTRACT:

Background

This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age groups. The data emphasize the importance of these master regulators in the transcriptional machinery of melanocytic neoplasms and suggest that differential levels of expressions of these miRs may contribute to differences in phenotypic and pathologic presentation of melanocytic neoplasms at different ages.

Methods

An exploratory miRNA analysis of 666 miRs by low density microRNA arrays was conducted on formalin fixed and paraffin embedded tissues (FFPE) from 10 older adults and 10 young adults including conventional melanoma and melanocytic neoplasms of uncert

SUBMITTER: Jukic DM 

PROVIDER: S-EPMC2855523 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature