A comprehensive molecular interaction map for rheumatoid arthritis.

ABSTRACT:

Background

Computational biology contributes to a variety of areas related to life sciences and, due to the growing impact of translational medicine--the scientific approach to medicine in tight relation with basic science--, it is becoming an important player in clinical-related areas. In this study, we use computation methods in order to improve our understanding of the complex interactions that occur between molecules related to Rheumatoid Arthritis (RA).

Methodology

Due to the complexity of the disease and the numerous molecular players involved, we devised a method to construct a systemic network of interactions of the processes ongoing in patients affected by RA. The network is based on high-throughput data, refined semi-automatically with carefully curated literature-

SUBMITTER: Wu G 

PROVIDER: S-EPMC2855702 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature