Common germ-line polymorphism of C1QA and breast cancer survival.

ABSTRACT:

Background

A synonymous single nucleotide polymorphism (SNP) rs172378 (A>G, Gly->Gly) in the complement component C1QA has been proposed to be associated with distant breast cancer metastasis. We previously reported overexpression of this gene to be significantly associated with better prognosis in oestrogen-receptor-negative tumours. The purpose of this study was to investigate the association of rs172378 with expression of C1QA and breast cancer survival.

Methods

We analysed the gene expression pattern of rs172378 in normal and tumour tissue samples, and further explored its involvement in relation to mortality in 2270 women with breast cancer participating in Studies of Epidemiology and Risk factors in Cancer Heredity, a population-based case-control study.

Results

SUBMITTER: Azzato EM 

PROVIDER: S-EPMC2856004 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature