Translational regulation of gene expression by an anaerobically induced small non-coding RNA in Escherichia coli.

ABSTRACT: Small non-coding RNAs (sRNA) have emerged as important elements of gene regulatory circuits. In enterobacteria such as Escherichia coli and Salmonella many of these sRNAs interact with the Hfq protein, an RNA chaperone similar to mammalian Sm-like proteins and act in the post-transcriptional regulation of many genes. A number of these highly conserved ribo-regulators are stringently regulated at the level of transcription and are part of major regulons that deal with the immediate response to various stress conditions, indicating that every major transcription factor may control the expression of at least one sRNA regulator. Here, we extend this view by the identification and characterization of a highly conserved, anaerobically induced small sRNA in E. coli, whose expression is strictly d

SUBMITTER: Boysen A 

PROVIDER: S-EPMC2856277 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature