The SF-36 and SGRQ: validity and first look at minimum important differences in IPF.

ABSTRACT:

Rationale

Health-related quality of life (HRQL) is an important outcome in drug trials. Little is known about how the Short Form-36 (SF-36) and Saint George's Respiratory Questionnaire (SGRQ) perform in idiopathic pulmonary fibrosis (IPF).

Objectives

To examine the validity of the SF-36 and SGRQ and to determine scores from each that would constitute a minimum important difference (MID).

Methods

We analyzed data from a recently completed trial that enrolled subjects with well-defined IPF who completed the SF-36, SGRQ, and Baseline/Transition Dyspnea Index at baseline and six months. We compared mean changes in HRQL scores between groups of subjects whose disease severity changed over six months according to clinical anchors (FVC, DLCO, and dyspnea). We estimated the M

SUBMITTER: Swigris JJ 

PROVIDER: S-EPMC2856332 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature