Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes.

ABSTRACT:

Background

Insulin-like growth factor-I (IGF-I) and insulin stimulate cell proliferation in uterine leiomyoma (fibroid) tissue. We hypothesized that circulating levels of these proteins would be associated with increased prevalence and size of uterine fibroids.

Methods

Participants were 35-49-year-old, randomly selected members of an urban health plan who were enrolled in the study in 1996-1999. Premenopausal participants were screened for fibroids with ultrasound. Fasting blood samples were collected. Associations between fibroids and diabetes, plasma IGF-I, IGF binding protein 3 (BP3), and insulin were evaluated for blacks (n = 585) and whites (n = 403) by using multiple logistic regression.

Results

IGF-I showed no association with fibroids in blacks, but in whites

SUBMITTER: Baird DD 

PROVIDER: S-EPMC2856640 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature