PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study.

ABSTRACT:

Background and objectives

Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders.

Methods

Using a tagSNP approach, and data from the Cardiovascular Health Study (CHS), we assessed associations of common polymorphisms of PROC, PROS1 and PROCR with: (i) plasma protein C, soluble protein C endothelial receptor (sEPCR) and protein S levels measured in a subsample of 336 participants at study entry; and (ii) risk of incident clinical outcomes [coronary heart disease (CHD), stroke, and mortality] in 4547 participants during follow-up. Secondarily, we explored associations between plasma protein C, protein S and sEPCR levels and other candidate genes involved in thrombosis, inflammation, and aging.

Results

The PR

SUBMITTER: Reiner AP 

PROVIDER: S-EPMC2856703 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature