Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival.

ABSTRACT: Complementary deoxyribonucleic acid microarray data from 36 mice subjected for 1, 2, or 4 weeks of their early life to normal atmospheric conditions (normoxia) or chronic intermittent (CIH) or constant (CCH) hypoxia were analyzed to extract organizational principles of the developing heart transcriptome and determine the integrated response to oxygen deprivation. Although both CCH and CIH regulated numerous genes involved in a wide diversity of processes, the changes in maturational profile, expression stability, and coordination were vastly different between the two treatments, indicating the activation of distinct regulatory mechanisms of gene transcription. The analysis focused on the main regulators of translation and response to stress because of their role in the cardiac hypertrophy

SUBMITTER: Iacobas DA 

PROVIDER: S-EPMC2856931 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature