ZAP-70: an essential kinase in T-cell signaling.

ABSTRACT: ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.

SUBMITTER: Wang H 

PROVIDER: S-EPMC2857167 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature