Signal amplification in a microchannel from redox cycling with varied electroactive configurations of an individually addressable microband electrode array.

ABSTRACT: Amperometric detection at microelectrodes in lab-on-a-chip (LOAC) devices lose advantages in signal-to-background ratio, reduced ohmic iR drop, and steady-state signal when volumes are so small that diffusion fields reach the walls before flux becomes fully radial. Redox cycling of electroactive species between multiple, closely spaced microelectrodes offsets that limitation and provides amplification capabilities. A device that integrates a microchannel with an individually addressable microband electrode array has been used to study effects of signal amplification due to redox cycling in a confined, static solution with different configurations and numbers of active generators and collectors. The microfabricated device consists of a 22 microm high, 600 microm wide microchannel containing

SUBMITTER: Lewis PM 

PROVIDER: S-EPMC2857402 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature