Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy.

ABSTRACT:

Background

A large gene region, called GD-1, was first described by this laboratory as linked to Graves' disease (GD) and included the gene for the thyroid-stimulating hormone receptor (TSHR). Recent studies have now suggested an association of TSHR intronic polymorphisms with GD. We have taken the opportunity to examine a population of well-characterized patients with autoimmune thyroid disease (AITD) typed for an additional thyroid susceptibility gene, the immunoregulatory gene for cytotoxic T-lymphocyte antigen 4 (CTLA-4), to examine its relationship with the susceptibility to GD endowed by TSHR gene polymorphisms.

Methods

We used TSHR-SNP-rs2268458, located in intron 1 of the TSHR gene, measured using standard PCR-RFLP procedures, as our marker for the TSHR gene associat

SUBMITTER: Yin X 

PROVIDER: S-EPMC2857451 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature