Ontology highlight
ABSTRACT:
SUBMITTER: Alkalaeva E
PROVIDER: S-EPMC2857517 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
FEBS letters 20090929 21
Although some data link archaeal and eukaryotic translation, the overall mechanism of protein synthesis in archaea remains largely obscure. Both archaeal (aRF1) and eukaryotic (eRF1) single release factors recognize all three stop codons. The archaeal genus Methanosarcinaceae contains two aRF1 homologs, and also uses the UAG stop to encode the 22nd amino acid, pyrrolysine. Here we provide an analysis of the last stage of archaeal translation in pyrrolysine-utilizing species. We demonstrated that ...[more]