Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA).

ABSTRACT:

Background

Our objective was to develop a consistent molecular definition of psoriasis. There have been several published microarray studies of psoriasis, and we compared disease-related genes identified across these different studies of psoriasis with our own in order to establish a consensus.

Methodology/principal findings

We present a psoriasis transcriptome from a group of 15 patients enrolled in a clinical study, and assessed its biological validity using a set of important pathways known to be involved in psoriasis. We also identified a key set of cytokines that are now strongly implicated in driving disease-related pathology, but which are not detected well on gene array platforms and require more sensitive methods to measure mRNA levels in skin tissues. Comparison of

SUBMITTER: Suarez-Farinas M 

PROVIDER: S-EPMC2857878 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature