Relative roles of the different Pax6 domains for pancreatic alpha cell development.

ABSTRACT:

Background

The transcription factor Pax6 functions in the specification and maintenance of the differentiated cell lineages in the endocrine pancreas. It has two DNA binding domains, the paired domain and the homeodomain, in addition to a C-terminal transactivation domain. The phenotype of Pax6-/- knockout mice suggests non-redundant functions of the transcription factor in the development of glucagon-expressing alpha-cells as this cell type is absent in the mutants. We ask the question of how the differentiation of pancreatic endocrine cells, in particular that of alpha-cells, is affected by selective inactivation of either one of the three major domains of Pax6.

Results

The Pax6Aey18 mutant mouse line, in which the paired domain is inactivated, showed a phenotype similar t

SUBMITTER: Dames P 

PROVIDER: S-EPMC2858030 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature