Transcriptional analysis of the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium yoelii.

ABSTRACT: The molecular biology of the clinically silent pre-erythrocytic stages of mammalian Plasmodium spp, composed of both the sporozoite and liver stages, has remained largely uncharacterized. Improved understanding of the biological processes required for progression through the pre-erythrocytic stages could lead to the identification of novel drug and vaccine targets. To gain insights into the molecular events that occur during the pre-erythrocytic stages of Plasmodium, comparative transcriptional analysis was performed on radiation attenuated sporozoites (RAS), wild type sporozoites (wtSPZ) and liver stage parasites collected either 24 hours (24hrLS) or 48 hours (48hrLS) after mice were infected with Plasmodium yoelii. Our results revealed 1100 Plasmodium genes that were differentially expre

SUBMITTER: Williams CT 

PROVIDER: S-EPMC2858153 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature