Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration.

ABSTRACT:

Background

Precise regulation of the cell cycle is crucial to the growth and development of all organisms. Understanding the regulatory mechanism of the cell cycle is crucial to unraveling many complicated diseases, most notably cancer. Multiple sources of biological data are available to study the dynamic interactions among many genes that are related to the cancer cell cycle. Integrating these informative and complementary data sources can help to infer a mutually consistent gene transcriptional regulatory network with strong similarity to the underlying gene regulatory relationships in cancer cells.

Results and principal findings

We propose an integrative framework that infers gene regulatory modules from the cell cycle of cancer cells by incorporating multiple sources of

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2858157 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature