Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes.

ABSTRACT:

Objective

Reduction of bone marrow-derived circulating progenitor cells has been proposed as a novel mechanism of cardiovascular disease in type 2 diabetes. The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes.

Research design and methods

We identified 425 individuals, divided into seven categories according to carbohydrate metabolism status (normal glucose tolerance [NGT], impaired fasting glucose, impaired glucose tolerance [IGT], and newly diagnosed type 2 diabetes) and diabetes duration (0-9, 10-19, and >or=20 years). These categories were examined as ideally describing the natural history of type 2 diabetes development and progression. We measured CD34+ and CD34+KDR+ pro

SUBMITTER: Fadini GP 

PROVIDER: S-EPMC2858183 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature