Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recently published an equation for estimated glomerular filtration rate (eGFR) using the same variables (serum creatinine level, age, sex, and race) as the Modification of Diet in Renal Disease (MDRD) Study equation. Although the CKD-EPI equation estimates GFR more precisely compared with the MDRD Study equation, whether this equation improves risk prediction is unknown.

Study design

Prospective cohort study, the Atherosclerosis Risk in Communities (ARIC) Study.

Setting & participants

13,905 middle-aged participants without a history of cardiovascular disease with median follow-up of 16.9 years.

Predictor

eGFR.

Outcomes & measurements

We compared the association of eGFR in categor

SUBMITTER: Matsushita K 

PROVIDER: S-EPMC2858455 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature