Alignment-free local structural search by writhe decomposition.

ABSTRACT:

Motivation

Rapid methods for protein structure search enable biological discoveries based on flexibly defined structural similarity, unleashing the power of the ever greater number of solved protein structures. Projection methods show promise for the development of fast structural database search solutions. Projection methods map a structure to a point in a high-dimensional space and compare two structures by measuring distance between their projected points. These methods offer a tremendous increase in speed over residue-level structural alignment methods. However, current projection methods are not practical, partly because they are unable to identify local similarities.

Results

We propose a new projection-based approach that can rapidly detect global as well as local stru

SUBMITTER: Zhi D 

PROVIDER: S-EPMC2859133 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature