Building and analyzing protein interactome networks by cross-species comparisons.

ABSTRACT:

Background

A genomic catalogue of protein-protein interactions is a rich source of information, particularly for exploring the relationships between proteins. Numerous systems-wide and small-scale experiments have been conducted to identify interactions; however, our knowledge of all interactions for any one species is incomplete, and alternative means to expand these network maps is needed. We therefore took a comparative biology approach to predict protein-protein interactions across five species (human, mouse, fly, worm, and yeast) and developed InterologFinder for research biologists to easily navigate this data. We also developed a confidence score for interactions based on available experimental evidence and conservation across species.

Results

The connectivity of the

SUBMITTER: Wiles AM 

PROVIDER: S-EPMC2859380 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature