Legionella pneumophila pangenome reveals strain-specific virulence factors.

ABSTRACT:

Background

Legionella pneumophila subsp. pneumophila is a gram-negative gamma-Proteobacterium and the causative agent of Legionnaires' disease, a form of epidemic pneumonia. It has a water-related life cycle. In industrialized cities L. pneumophila is commonly encountered in refrigeration towers and water pipes. Infection is always via infected aerosols to humans. Although many efforts have been made to eradicate Legionella from buildings, it still contaminates the water systems. The town of Alcoy (Valencian Region, Spain) has had recurrent outbreaks since 1999. The strain "Alcoy 2300/99" is a particularly persistent and recurrent strain that was isolated during one of the most significant outbreaks between the years 1999-2000.

Results

We have sequenced the genome of the par

SUBMITTER: D'Auria G 

PROVIDER: S-EPMC2859405 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature