Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis.

ABSTRACT:

Background

Uncovering the molecular mechanisms involved in epileptogenesis is critical to better understand the physiopathology of epilepsies and to help develop new therapeutic strategies for this prevalent and severe neurological condition that affects millions of people worldwide.

Results

Changes in the transcriptome of hippocampal cells from rats subjected to the pilocarpine model of epilepsy were evaluated by microarrays covering 34,000 transcripts representing all annotated rat genes to date. Using such genome-wide approach, differential expression of nearly 1,400 genes was detected during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures. Most of these genes are novel and displayed an up-re

SUBMITTER: Okamoto OK 

PROVIDER: S-EPMC2859406 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature