Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes.

ABSTRACT: Islet transplantation is a promising therapy used to achieve glycometabolic control in a select subgroup of individuals with type I diabetes. However, features that characterize human islet isolation success prior to transplantation are not standardized and lack validation. We conducted a retrospective analysis of 806 isolation records from 14 pancreas-processing laboratories, considering variables from relevant studies in the last 15 years. The outcome was defined as post-purification islet equivalent count, dichotomized into yields > or =315 000 or < or =220 000. Univariate analysis showed that donor cause of death and use of hormonal medications negatively influenced outcome. Conversely, pancreata from heavier donors and those containing elevated levels of surface fat positively influen

SUBMITTER: Kaddis JS 

PROVIDER: S-EPMC2860018 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature