Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2.

ABSTRACT:

Background

The continuation of developing Herpes simplex virus type-2 (HSV-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines.

Methods

Using mathematical modeling we derived 3 summary measures for the population effect of imperfect HSV-2 vaccines as a function of their efficacies in reducing susceptibility (VES), genital shedding (VEP), and infectivity during shedding (VEI). In addition, we studied the population level effect of vaccine intervention using representative vaccine efficacies.

Results

A vaccine with limited efficacy of reducing shedding frequency (VEP = 10%) and infectivity (VEI = 0%) would need to reduce susceptibility by 75% (VES = 75%) to substantially reduce the sustainability of

SUBMITTER: Alsallaq RA 

PROVIDER: S-EPMC2860045 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature