Enantioselective alkenylation via nickel-catalyzed cross-coupling with organozirconium reagents.

ABSTRACT: A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary alpha-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile beta,gamma-unsaturated ketones with good enantioselectivity.

SUBMITTER: Lou S 

PROVIDER: S-EPMC2860276 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature