Deciphering the mesodermal potency of porcine skin-derived progenitors (SKP) by microarray analysis.

ABSTRACT: Skin stem cells have an essential role in maintaining tissue homeostasis by dynamically replenishing those constantly lost during tissue turnover or following injury. Multipotent skin derived progenitors (SKP) can generate both neural and mesodermal progeny, representing neural crest-derived progenitors during embryogenesis through adulthood. SKP cells develop into spheres in suspension and can differentiate into fibroblast-like cells (SFC) in adhesive culture with serum. Concomitantly they gradually lose the neural potential but retain certain mesodermal potential. However, little is known about the molecular mechanism of the transition of SKP spheres into SFC in vitro. Here we characterized the transcriptional profiles of porcine SKP spheres and SFC by microarray analysis. We found 305 u

SUBMITTER: Zhao MT 

PROVIDER: S-EPMC2860391 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature