Association between mammographic density and age-related lobular involution of the breast.

ABSTRACT:

Purpose

Mammographic density and lobular involution are both significant risk factors for breast cancer, but whether these reflect the same biology is unknown. We examined the involution and density association in a large benign breast disease (BBD) cohort.

Patients and methods

Women in the Mayo Clinic BBD cohort who had a mammogram within 6 months of BBD diagnosis were eligible. The proportion of normal lobules that were involuted was categorized by an expert pathologist as no (0%), partial (1% to 74%), or complete involution (>or= 75%). Mammographic density was estimated as the four-category parenchymal pattern. Statistical analyses adjusted for potential confounders and evaluated modification by parity and age. We corroborated findings in a sample of women with BBD from t

SUBMITTER: Ghosh K 

PROVIDER: S-EPMC2860438 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature