Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort.

ABSTRACT:

Objective

Prior studies have shown improved neurocognition with initiation of antiretroviral treatment (ART) in HIV. We hypothesized that stopping ART would be associated with poorer neurocognitive function.

Methods

Neurocognitive function was assessed as part of ACTG 5170, a multicenter, prospective observational study of HIV-infected subjects who elected to discontinue ART. Eligible subjects had CD4 count >350 cells/mm(3), had HIV RNA viral load <55,000 cp/mL, and were on ART (>or=2 drugs) for >or=6 months. Subjects stopped ART at study entry and were followed for 96 weeks with a neurocognitive examination.

Results

A total of 167 subjects enrolled with a median nadir CD4 of 436 cells/mm(3) and 4.5 median years on ART. Significant improvements in mean neuropsychologi

SUBMITTER: Robertson KR 

PROVIDER: S-EPMC2860482 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature