Mechanisms and inhibition of HIV integration.

ABSTRACT: HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.

SUBMITTER: Marchand C 

PROVIDER: S-EPMC2860614 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature