Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in mice.

ABSTRACT:

Background

The tumor microenvironment has been described as a critical milieu determining tumor growth and metastases. A pivotal role of metastasis-inducing S100A4 in the development of tumor stroma has been proven in animal models and verified in human breast cancer biopsies. Expression and release of S100A4 has been shown in various types of stroma composing cells, including fibroblasts and immune cells. However, the events implicated in upstream and downstream pathways regulating the activity of the extracellular S100A4 protein in the tumor milieu remain unsolved.

Methodology/principal findings

We studied the interplay between the tumor cell-derived cytokine regulated-upon-activation, normal T-cell expressed and secreted (RANTES; CCL5) and S100A4 which were shown to be cr

SUBMITTER: Forst B 

PROVIDER: S-EPMC2860983 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature