Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner.

ABSTRACT:

Background

Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic development through the induction of oxidative stress and inflammation, a lung cancer risk factor. Vanadium pentoxide (V2O5) is a component of PM derived from fuel combustion as well as a source of occupational exposure in humans. In the current investigation we examined the influence of genetic background on susceptibility to V2O5-induced inflammation and evaluated whether V2O5 functions as a tumor promoter using a 2-stage (initiation-promotion) model of pulmonary neoplasia in mice.

Results

A/J, BALB/cJ (BALB), and C57BL/6J (B6) mice were treated either with the initiator 3-methylcholanthrene (MCA; 1

SUBMITTER: Rondini EA 

PROVIDER: S-EPMC2861012 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature