Urinary biomarkers for the early diagnosis of kidney cancer.

ABSTRACT:

Objective

To test the hypothesis that increased tumor expression of proteins such as aquaporin-1 (AQP1) and adipophilin (ADFP) in patients with renal cancer would result in increased urine AQP1 and ADFP excretion.

Patients and methods

Prenephrectomy and postnephrectomy (pseudocontrol) urine samples were collected from 42 patients with an incidental radiographically discovered renal mass and presurgical presumptive diagnosis of kidney cancer from July 8, 2008, through March 10, 2009. Also enrolled were 15 control patients who underwent nonrenal surgery and 19 healthy volunteers. Urine AQP1 and ADFP concentrations normalized to urine creatinine were determined by sensitive and specific Western blot assays.

Results

Mean +/- SD preexcision urine AQP1 and ADFP concentratio

SUBMITTER: Morrissey JJ 

PROVIDER: S-EPMC2861969 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature