Effect of amitriptyline on symptoms in treatment naive patients with interstitial cystitis/painful bladder syndrome.

ABSTRACT:

Purpose

Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome. The evidence to support this practice is derived mainly from a small, single site clinical trial and case reports.

Materials and methods

We conducted a multicenter, randomized, double-blind, placebo controlled clinical trial of amitriptyline in subjects with interstitial cystitis/painful bladder syndrome who were naïve to therapy. Study participants in both treatment arms received a standardized education and behavioral modification program. The drug dose was increased during a 6-week period from 10 up to 75 mg once daily. The primary outcome was a patient reported global response assessment of symptom improvement evaluated after 12 weeks of treatment.

Results</

SUBMITTER: Foster HE 

PROVIDER: S-EPMC2861998 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature