High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography.

ABSTRACT:

Background

For evaluation of patients with chest pain and suspected acute coronary syndrome (ACS), consensus guidelines recommend use of a cardiac troponin cut point that corresponds to the 99 th percentile of a healthy population. Most conventional troponin methods lack sufficient precision at this low level.

Methods and results

In a cross-sectional study, 377 patients (mean age 53.7 years, 64.2% male) with chest pain and low to intermediate likelihood for ACS were enrolled in the emergency department. Blood was tested with a precommercial high-sensitivity troponin T assay (hsTnT) and compared with a conventional cardiac troponin T method. Patients underwent a 64-slice coronary computed tomography coronary angiogram at the time of phlebotomy, on average 4 hours from initial

SUBMITTER: Januzzi JL 

PROVIDER: S-EPMC2862312 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature